📷 Image Credits: The Hindu
Wasp venom contains a peptide that has the potential to be developed into a new antibiotic with bacteria-killing properties without harming human cells. Researchers have repurposed this toxic molecule into a viable molecule for treating infections by analyzing the structure and function of these peptides. The study, conducted by a team of scientists led by microbiologist and immunologist Cesar de la Fuente-Nunez of MIT, focused on a peptide found in the venom of a South American wasp called Polybia paulista.
Antimicrobial peptides are produced by all classes of life on the planet to defend against infections. With the alarming rise of antibiotic-resistant bacteria globally, developing new antibiotics is crucial. Adapting antimicrobial peptides into antibiotics is a challenging task, but one that holds promise in the fight against superbugs.
The researchers developed several variants of the peptide and tested them against various bacteria and fungi to determine their effectiveness in interacting with cell membranes. Refining the peptides based on these interactions, the team then assessed their toxicity on human cells to establish a safe dose level. Subsequently, the most promising peptides were tested on mice infected with antibiotic-resistant bacteria, Pseudomonas aeruginosa.
One peptide stood out for its ability to completely eradicate the infection at a high dose in the mouse model. This result was surprising and exciting, as it showcased a level of efficacy not typically seen with other experimental antimicrobials or antibiotics. Further research is needed to determine if the efficacy can be maintained at lower, safer doses.
While the research on developing an antibiotic from wasp venom is ongoing, the methods established by the researchers can be applied to other antimicrobial peptides for a wider range of solutions in combating antibiotic-resistant infections. The study highlights the importance of exploring novel sources for antibiotic development in the ever-evolving field of medical research.
